{"text_format":"1","workbook":"xlsx","n_sheets":11,"sheets":["Main","EmpiricVANCOMYCINcalc","EmpiricNote","EmpWorksheet","TwoLevelVANCOMYCINcalc","TLKnote","TLKworksheet","EmpiricAMGcalc","AmgEmpWS","DLsheet","WeMadeThis"],"not_rendered":{"charts":5,"images":4,"macros":1,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Main","index":0,"n_rows":40,"n_cols":18,"rows_kept":40,"cut":false,"hidden":false,"merged":[[4,17,5,21],[39,11,40,14],[16,6,20,10],[25,6,29,10],[16,17,20,22],[25,17,29,22]]}
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[null,null,null,null,null,null,null,null,null,null,null,null,null,"Clinical calculators are tools used by professionals, in conjunction with clinical judgement, in order to make complex medical decisions"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,"This calculator is not a substitute for advanced knowledge in drug dosing"]
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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Acknowledgements"]
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[null,null,null,null,null,null,"Vancomycin Empiric Dosing",null,null,null,null,null,null,null,null,null,null,"Vancomycin Two-level Dosing"]
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[null,null,null,null,null,null,null,null,null,null,null,"Edit Default Values"]

{"sheet":"EmpiricVANCOMYCINcalc","index":1,"n_rows":37,"n_cols":25,"rows_kept":37,"cut":false,"hidden":false,"merged":[[15,21,15,25],[9,21,9,25],[10,21,10,25],[11,21,11,25],[12,21,12,25],[2,17,3,23],[0,17,1,23],[4,6,5,12],[9,4,9,5],[10,4,10,5],[4,17,5,23],[8,14,8,25],[17,4,17,5],[18,4,18,5],[19,4,19,5],[8,1,8,7],[12,6,12,7],[13,6,13,7],[11,4,11,5],[12,4,12,5],[13,4,13,5],[15,4,15,5],[14,4,14,5],[16,4,16,5],[15,15,15,18],[17,15,17,18],[14,15,14,18],[18,15,18,18],[16,19,16,20],[16,15,16,18],[15,19,15,20],[17,19,17,20],[14,19,14,20],[18,19,18,20],[13,19,13,20],[12,19,12,20],[9,15,9,18],[10,15,10,18],[11,15,11,18],[13,15,13,18],[12,15,12,18],[9,19,9,20],[10,19,10,20],[11,19,11,20],[30,4,30,5],[20,18,22,25],[24,1,24,7],[24,14,24,20],[32,16,32,20],[25,16,25,18],[26,16,26,18],[27,16,27,18],[28,16,28,18],[29,16,29,18],[30,16,30,18],[25,4,25,5],[26,4,26,5],[27,4,27,5],[28,4,28,5],[29,4,29,5]]}
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Reset this Calculator"]
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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"View Patient Note"]
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[null,null,null,null,null,null,"Vancomycin Empiric Calculator",null,null,null,null,null,null,null,null,null,null,"Back to Main Menu"]
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[]
[]
[null,"Patient Information",null,null,null,null,null,null,null,null,null,null,null,null,"Dosing Variables"]
[null,"Age",null,null,null,null,"years",null,null,null,null,null,null,null,null,"Desired AUC",null,null,null,500,null,"Usual range 400-600 mcg*h/mL"]
[null,"Gender",null,null,null,null,null,null,null,null,null,null,null,null,null,"Desired Cmax",null,null,null,35,null,"Usual range 30-40 mcg/mL"]
[null,"SCr",null,null,null,null,"mg/dL",null,null,null,null,null,null,null,null,"Desired Cmin",null,null,null,12.5,null,"Usual range 10-20 mcg/mL"]
[null,"Height",null,null,null,null,"cm",null,{"$f":"IF(G13=\"inches\",E13,E13/2.54)","v":0},{"$f":"I13*2.54","v":0},null,null,null,null,null,"Vd coefficient",null,null,null,0.65,null,"Usual range 0.6-1 L/kg"]
[null,"Actual Body Weight",null,"TBW",null,null,"kg",null,{"$f":"IF(G14=\"kg\",E14,E14/2.2)","v":0},null,null,null,null,null,null,"Weight to calculate Vd",null,null,null,"TBW",null,{"$f":"IF(T15>0,T15,IF(T14<1,\"\",VLOOKUP(T14,D14:F21,2,FALSE)))","v":0},"kg",{"$f":"IF(ISERROR(I14>DLsheet!H7*EmpiricVANCOMYCINcalc!E16),\"TBW\",IF(EmpiricVANCOMYCINcalc!I14>DLsheet!H6*EmpiricVANCOMYCINcalc!E16,\"AdjBW\",\"TBW\"))","v":"TBW"},"recommended to calculate Vd for this patient"]
[null,null,null,"AdjBW",{"$f":"IF(E14<1,\"\",IF(I14>DLsheet!H6*EmpiricVANCOMYCINcalc!E16,EmpiricVANCOMYCINcalc!E16+DLsheet!H7*(EmpiricVANCOMYCINcalc!E14-EmpiricVANCOMYCINcalc!E16),\"\"))","v":""},null,"kg",null,{"$f":"CONCATENATE(\"IBW + \",DLsheet!H7,\"* (TBW - IBW) If TBW more than \",DLsheet!G6*100,\"% overweight\")","v":"IBW + 0.4* (TBW - IBW) If TBW more than 30% overweight"},null,null,null,null,null,null,"Manual Dosing Weight (override)",null,null,null,null,null,"kg"]
[null,null,null,"IBW",{"$f":"IF(E14<1,\"\",IF(E11=\"Male\",50+2.3*(I13-60),45.5+2.3*(I13-60)))","v":""},null,"kg",null,"M: 2.3*(inches over 60)+50   F: 2.3*(inches over 60)+45.5",null,null,null,null,null,null,"Ke equation",null,null,null,"CrCl*0.00083+0.0044",null,"See comment"]
[null,null,null,"LBW",{"$f":"IF(E14<1,\"\",IF(E11=\"Male\",L17,M17))","v":""},null,"kg",null,"James Formula",null,null,{"$f":"1.1*I14-128*I14*I14/J13/J13","v":{"$error":"#DIV/0!"}},{"$f":"1.07*I14-148*I14*I14/J13/J13","v":{"$error":"#DIV/0!"}},null,null,"Weight to calculate CrCl & Ke",null,null,null,"CrCl TBW",null,{"$f":"IF(T18>0,T18,IF(T17<1,\"\",VLOOKUP(T17,D14:F20,2,FALSE)))","v":""},"mL/min",{"$f":"IF(ISERROR(I14>DLsheet!H6*EmpiricVANCOMYCINcalc!E16),\"CrCl TBW\",IF(EmpiricVANCOMYCINcalc!I14>DLsheet!H6*EmpiricVANCOMYCINcalc!E16,\"CrCl AdjBW\",IF(I14<E16,\"CrCl TBW\",\"CrCl IBW\")))","v":"CrCl TBW"},"recommended to calculate CrCl for this patient"]
[null,null,null,"CrCl TBW",{"$f":"IF(E14<1,\"\",IF(E11=\"Male\",(140-E10)*E14/72/E12,0.85*(140-E10)*E14/72/E12))","v":""},null,"mL/min",null,"(140-Age)*TBW/[72*SCr]  (females * 0.85)",null,null,null,null,null,null,"Manual CrCl (override)",null,null,null,null,null,"mL/min"]
[null,null,null,"CrCl AdjBW",{"$f":"IF(E15=\"\",\"\",IF(E11=\"Male\",(140-E10)*E15/72/E12,0.85*(140-E10)*E15/72/E12))","v":""},null,"mL/min",null,"(140-Age)*AdjBW/[72*SCr]  (females * 0.85)",null,null,null,null,null,null,"Infusion time",null,null,null,1,null,"hours"]
[null,null,null,"CrCl IBW",{"$f":"IF(E14<1,\"\",IF(E11=\"Male\",(140-E10)*E16/72/E12,0.85*(140-E10)*E16/72/E12))","v":""},null,"mL/min",null,"(140-Age)*IBW/[72*SCr]  (females * 0.85)"]
[null,null,null,null,null,null,null,null,null,null,"CrCl*0.0016",{"$f":"V17*0.0016","v":{"$error":"#VALUE!"}},null,null,null,"Ke equation comment:",null,null,{"$f":"IF(T16<1,\"\",VLOOKUP(T16,DLsheet!K14:L16,2,FALSE))","v":"Less aggressive equation. Study included patienst with varying degrees of renal dysfunction. Consider in patients with significant comorbidities (e.g. long-standing DM, CHF, CKD)."}]
[null,null,null,null,null,null,null,null,null,null,"CrCl*0.00083+0.0044",{"$f":"V17*0.00083+0.0044","v":{"$error":"#VALUE!"}}]
[null,null,null,null,null,null,null,null,null,null,"CrCl/Vd",{"$f":"V17/E26*60/1000","v":{"$error":"#VALUE!"}}]
[]
[null,"Calculated PK Parameters",null,null,null,null,null,null,null,null,null,null,null,null,"Dosing Variables"]
[null,null,null,"Vd",{"$f":"IF(E14<1,\"\",T13*V14)","v":""},null,null,"L",{"$f":"CONCATENATE(ROUND(V14,1),\"kg * \",T13,\" L/kg\")","v":"0kg * 0.65 L/kg"},null,null,null,null,null,null,"Dose",{"$f":"EmpWorksheet!AB1","v":{"$error":"#VALUE!"}},null,null,"mg"]
[null,null,null,"Ke",{"$f":"IF(E14<1,\"\",VLOOKUP(T16,K21:L23,2,FALSE))","v":""},null,null,"h-1",{"$f":"CONCATENATE(\"CrCl = \",ROUND(V17,1),\"  Ke equation = \",T16)","v":{"$error":"#VALUE!"}},null,null,null,null,null,null,"Interval",{"$f":"EmpWorksheet!AC1","v":{"$error":"#VALUE!"}},null,null,"hours"]
[null,null,null,"t 1/2",{"$f":"IF(E14<1,\"\",ROUND(0.693/E27,1))","v":""},null,null,"hours",{"$f":"CONCATENATE(\"ln(2)/\", ROUND(E27,3))","v":{"$error":"#VALUE!"}},null,null,null,null,null,null,"Infusion Time",{"$f":"VLOOKUP(Q26,DLsheet!E13:F21,2,FALSE)","v":{"$error":"#VALUE!"}},null,null,"hours"]
[null,null,null,"Calculated total daily dose",{"$f":"IF(E14<1,\"\",T10*E27*E26)","v":""},null,null,"mg",{"$f":"CONCATENATE(\"(Desired AUC)*(Ke)*(Vd) = \",T10,\" * \",ROUND(E27,3),\" * \",ROUND(E26,1))","v":{"$error":"#VALUE!"}},null,null,null,null,null,null,"Calculated AUC",{"$f":"Q26*24/Q27/E27/E26","v":{"$error":"#VALUE!"}},null,null,"mcg*h/mL"]
[null,null,null,"Calculated dose",{"$f":"IF(E14<1,\"\",E29/(24/E31))","v":""},null,null,"mg","Total daily dose / (24/[calculated interval])",null,null,null,null,null,null,"Calculated Css max",{"$f":"(Q26/E26)/(1-EXP(-E27*Q27))","v":{"$error":"#VALUE!"}},null,null,"mcg/mL"]
[null,null,null,"Calculated interval",{"$f":"IF(E14<1,\"\",(LN(T12/T11)/-E27)+T19)","v":""},null,null,"hours","(ln[desired trough]/[desired peak] / [-Ke]) + infusion time",null,null,null,null,null,null,"Calculated Css min",{"$f":"Q30*EXP(-E27*(Q27-Q28))","v":{"$error":"#VALUE!"}},null,null,"mcg/mL"]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Alternative Dosing Regimens"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"EstAUC","Cmax","Cmin"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,1,{"$f":"CONCATENATE(EmpWorksheet!AB1,\"mg IV q\",EmpWorksheet!AC1,\"h\")","v":{"$error":"#VALUE!"}},null,{"$f":"ROUND(EmpWorksheet!AG1,1)","v":{"$error":"#VALUE!"}},{"$f":"ROUND(EmpWorksheet!AE1,1)","v":{"$error":"#VALUE!"}},{"$f":"ROUND(EmpWorksheet!AF1,1)","v":{"$error":"#VALUE!"}}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,2,{"$f":"CONCATENATE(EmpWorksheet!AB2,\"mg IV q\",EmpWorksheet!AC2,\"h\")","v":{"$error":"#VALUE!"}},null,{"$f":"ROUND(EmpWorksheet!AG2,1)","v":{"$error":"#VALUE!"}},{"$f":"ROUND(EmpWorksheet!AE2,1)","v":{"$error":"#VALUE!"}},{"$f":"ROUND(EmpWorksheet!AF2,1)","v":{"$error":"#VALUE!"}}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,3,{"$f":"CONCATENATE(EmpWorksheet!AB3,\"mg IV q\",EmpWorksheet!AC3,\"h\")","v":{"$error":"#VALUE!"}},null,{"$f":"ROUND(EmpWorksheet!AG3,1)","v":{"$error":"#VALUE!"}},{"$f":"ROUND(EmpWorksheet!AE3,1)","v":{"$error":"#VALUE!"}},{"$f":"ROUND(EmpWorksheet!AF3,1)","v":{"$error":"#VALUE!"}}]

{"sheet":"EmpiricNote","index":2,"n_rows":5,"n_cols":11,"rows_kept":5,"cut":false,"hidden":false,"merged":[[1,10,2,16],[4,10,5,16],[1,1,29,1]]}
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[null,{"$f":"DLsheet!L53","v":{"$error":"#VALUE!"}},null,null,null,null,null,null,null,null,"Back to Main Menu"]
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[null,null,null,null,null,null,null,null,null,null,"Back to Empiric Calculator"]

{"sheet":"EmpWorksheet","index":3,"n_rows":100,"n_cols":33,"rows_kept":100,"cut":false,"hidden":false,"merged":[]}
[{"$f":"EmpiricVANCOMYCINcalc!E27","v":""},{"$f":"EmpiricVANCOMYCINcalc!E26","v":""},8,12,18,24,36,48,null,"Cmax Error","Cmin Error","AUC Error","Total Error","Daily dose","Dose","interval","Usable interval","Infusion","Cmax","Cmin","AUC",null,null,null,"Best","Min",{"$f":"MIN(M2:M46)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA1,M:R,3,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA1,M:R,4,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA1,M:R,5,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA1,M:U,7,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA1,M:U,8,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA1,M:U,9,FALSE)","v":{"$error":"#VALUE!"}}]
[-0.5,0,0,0,0,0,0,0,null,{"$f":"((S2-EmpiricVANCOMYCINcalc!$T$11)^2)/EmpiricVANCOMYCINcalc!$T$11","v":{"$error":"#VALUE!"}},{"$f":"((T2-EmpiricVANCOMYCINcalc!$T$12)^2)/EmpiricVANCOMYCINcalc!$T$12","v":{"$error":"#VALUE!"}},{"$f":"((U2-EmpiricVANCOMYCINcalc!$T$10)^2)/EmpiricVANCOMYCINcalc!$T$10","v":{"$error":"#VALUE!"}},{"$f":"IF(Q2=\"Yes\",SUM(J2:L2),\"\")","v":{"$error":"#VALUE!"}},{"$f":"O2*24/P2","v":250},500,48,{"$f":"VLOOKUP(P2,DLsheet!$I$15:$J$20,2,FALSE)","v":"Yes"},{"$f":"VLOOKUP(O2,DLsheet!$E$13:$F$21,2,FALSE)","v":0.5},{"$f":"O2/$B$1/(1-EXP(-$A$1*P2))","v":{"$error":"#VALUE!"}},{"$f":"S2*EXP(-$A$1*(P2-R2))","v":{"$error":"#VALUE!"}},{"$f":"O2*24/P2/$B$1/$A$1","v":{"$error":"#VALUE!"}},null,null,null,"2nd Best","Second",{"$f":"SMALL(M2:M46,2)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA2,M:R,3,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA2,M:R,4,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA2,M:R,5,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA2,M:U,7,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA2,M:U,8,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA2,M:U,9,FALSE)","v":{"$error":"#VALUE!"}}]
[0,{"$f":"HLOOKUP(EmpiricVANCOMYCINcalc!$Q$27,EmpWorksheet!$C$1:$H$100,I3,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"EmpiricVANCOMYCINcalc!Q26/EmpiricVANCOMYCINcalc!E26","v":{"$error":"#VALUE!"}},{"$f":"EmpiricVANCOMYCINcalc!Q26/EmpiricVANCOMYCINcalc!E26","v":{"$error":"#VALUE!"}},{"$f":"EmpiricVANCOMYCINcalc!Q26/EmpiricVANCOMYCINcalc!E26","v":{"$error":"#VALUE!"}},{"$f":"EmpiricVANCOMYCINcalc!Q26/EmpiricVANCOMYCINcalc!E26","v":{"$error":"#VALUE!"}},{"$f":"EmpiricVANCOMYCINcalc!Q26/EmpiricVANCOMYCINcalc!E26","v":{"$error":"#VALUE!"}},{"$f":"EmpiricVANCOMYCINcalc!Q26/EmpiricVANCOMYCINcalc!E26","v":{"$error":"#VALUE!"}},3,{"$f":"((S3-EmpiricVANCOMYCINcalc!$T$11)^2)/EmpiricVANCOMYCINcalc!$T$11","v":{"$error":"#VALUE!"}},{"$f":"((T3-EmpiricVANCOMYCINcalc!$T$12)^2)/EmpiricVANCOMYCINcalc!$T$12","v":{"$error":"#VALUE!"}},{"$f":"((U3-EmpiricVANCOMYCINcalc!$T$10)^2)/EmpiricVANCOMYCINcalc!$T$10","v":{"$error":"#VALUE!"}},{"$f":"IF(Q3=\"Yes\",SUM(J3:L3),\"\")","v":""},333.33333333333331,500,36,{"$f":"VLOOKUP(P3,DLsheet!$I$15:$J$20,2,FALSE)","v":"No"},{"$f":"VLOOKUP(O3,DLsheet!$E$13:$F$21,2,FALSE)","v":0.5},{"$error":"#VALUE!"},{"$error":"#VALUE!"},{"$error":"#VALUE!"},null,null,null,"3rd Best","Third",{"$f":"SMALL(M2:M46,3)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA3,M:R,3,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA3,M:R,4,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA3,M:R,5,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA3,M:U,7,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA3,M:U,8,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"VLOOKUP(AA3,M:U,9,FALSE)","v":{"$error":"#VALUE!"}}]
[0.5,{"$f":"HLOOKUP(EmpiricVANCOMYCINcalc!$Q$27,EmpWorksheet!$C$1:$H$100,I4,FALSE)","v":{"$error":"#VALUE!"}},{"$f":"$C$3*EXP(-$A$1*EmpWorksheet!$A4)","v":{"$error":"#VALUE!"}},{"$f":"$C$3*EXP(-$A$1*EmpWorksheet!$A4)","v":{"$error":"#VALUE!"}},{"$f":"$C$3*EXP(-$A$1*EmpWorksheet!$A4)","v":{"$error":"#VALUE!"}},{"$f":"$C$3*EXP(-$A$1*EmpWorksheet!$A4)","v":{"$error":"#VALUE!"}},{"$f":"$C$3*EXP(-$A$1*EmpWorksheet!$A4)","v":{"$error":"#VALUE!"}},{"$f":"$C$3*EXP(-$A$1*EmpWorksheet!$A4)","v":{"$error":"#VALUE!"}},4,{"$f":"((S4-EmpiricVANCOMYCINcalc!$T$11)^2)/EmpiricVANCOMYCINcalc!$T$11","v":{"$error":"#VALUE!"}},{"$f":"((T4-EmpiricVANCOMYCINcalc!$T$12)^2)/EmpiricVANCOMYCINcalc!$T$12","v":{"$error":"#VALUE!"}},{"$f":"((U4-EmpiricVANCOMYCINcalc!$T$10)^2)/EmpiricVANCOMYCINcalc!$T$10","v":{"$error":"#VALUE!"}},{"$error":"#VALUE!"},375,750,48,{"$f":"VLOOKUP(P4,DLsheet!$I$15:$J$20,2,FALSE)","v":"Yes"},{"$f":"VLOOKUP(O4,DLsheet!$E$13:$F$21,2,FALSE)","v":1},{"$error":"#VALUE!"},{"$error":"#VALUE!"},{"$error":"#VALUE!"}]
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[null,null,null,null,null,null,"Vancomycin Two-Level Calculator",null,null,null,null,null,null,null,null,null,null,"Back to Main Menu"]
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[]
[]
[null,"Current Dosing Information",null,null,null,null,null,null,null,null,"Dosing Variables"]
[null,"First dose or steady state",null,null,"Steady State",null,null,null,null,null,null,"Desired AUC",500,null,null,"Usual range 400-600 mcg*h/mL"]
[null,"Dose",null,null,null,null,"mg",null,null,null,null,"Desired Cmax",35,null,null,"Usual range 30-40 mcg/mL"]
[null,"Dosing interval",null,null,null,null,"hrs",null,null,null,null,"Desired Cmin",12.5,null,null,"Usual range 10-20 mcg/mL"]
[null,"Duration of Infusion",null,null,null,null,"hrs",null,{"$f":"E13/24","v":"00:00:00"},null,null,"Infusion time",1,null,null,"hours"]
[null,"Date/Time of recent dose",null,null,{"$f":"TODAY()","v":"2021-06-17"},"06:00:00",{"$f":"E14+F14","v":"2021-06-17T06:00:00"},null,null,null,null,"Calculated Total Daily Dose",{"$f":"M10*E23*E27","v":{"$error":"#VALUE!"}},null,null,"mg over 24 hours"]
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[null,"Level 1 result",null,null,null,null,"mcg/mL",null,{"$f":"(G17-(G14+I13))*24","v":6},null,null,"Calculated interval",{"$f":"LN(M12/M11)/-E23+M13","v":{"$error":"#VALUE!"}},null,null,"hr"]
[null,"Date/Time of Level 1",null,null,{"$f":"TODAY()","v":"2021-06-17"},"12:00:00",{"$f":"E17+F17","v":"2021-06-17T12:00:00"},null,{"$f":"(G20-G17)*24","v":6}]
[]
[null,"Level 2 result",null,null,null,null,"mcg/mL"]
[null,"Date/Time of Level 2",null,null,{"$f":"TODAY()","v":"2021-06-17"},"18:00:00",{"$f":"E20+F20","v":"2021-06-17T18:00:00"}]
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[null,"Calculated PK Parameters",null,null,null,null,null,null,null,null,"AUC-based Dosing Regimen"]
[null,null,null,"Ke",{"$f":"IF(E11=0,\"\",(LN(E16/E19))/I17)","v":""},null,"hr-1",null,null,null,null,"Dose",{"$f":"TLKworksheet!AB1","v":{"$error":"#DIV/0!"}},null,null,"mg"]
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[null,null,null,"Cmax for this interval",{"$f":"IF(E23=\"\",\"\",E16/(EXP(-E23*I16)))","v":""},null,"mcg/mL",null,null,null,null,"Infusion Time",{"$f":"VLOOKUP(M23,DLsheet!E13:F21,2,FALSE)","v":{"$error":"#DIV/0!"}},null,null,"hours"]
[null,{"$f":"IF(G14=\"inches\",E14,E14/2.54)","v":17466.141732283464},null,"Cmin for this interval",{"$f":"IF(E12=\"\",\"\",IF(E12=\"N/A\",\"\",E25*EXP(-E23*(E12-E13))))","v":""},null,"mcg/mL",null,{"$f":"(E11/E13)*(1-EXP(-E23*E13))/(E23*E25)","v":{"$error":"#DIV/0!"}},null,null,"Calculated AUC",{"$f":"M23*24/M24/E23/E27","v":{"$error":"#DIV/0!"}},null,null,"mcg*h/mL"]
[null,null,null,"Vd",{"$f":"IF(E10=\"First Dose\",I26,IF(E10=\"Steady state\",I27,\"\"))","v":{"$error":"#DIV/0!"}},null,"L",null,{"$f":"(E11/E13)*(1-EXP(-E23*E13))/(E23*E25*(1-EXP(-E23*E12)))","v":{"$error":"#DIV/0!"}},null,null,"Calculated Css max",{"$f":"(M23/E27)/(1-EXP(-E23*M24))","v":{"$error":"#DIV/0!"}},null,null,"mcg/mL"]
[null,null,null,"Vancomycin CL",{"$f":"IF(E10=\"First Dose\",E23*I26*1000/60,IF(E10=\"Steady State\",E23*I27*1000/60,\"\"))","v":{"$error":"#VALUE!"}},null,"mL/min",null,null,null,null,"Calculated Css min",{"$f":"M27*EXP(-E23*(M24-M25))","v":{"$error":"#DIV/0!"}},null,null,"mcg/mL"]
[null,null,null,"Steady state AUC",{"$f":"IF(E12=\"\",\"\",IF(E12=\"N/A\",\"\",E11*(24/E12)/(E28*60/1000)))","v":""},null,"mcg*h/mL"]
[null,null,null,"at currrent dose/interval",null,null,null,null,null,null,null,null,"Alternative Dosing Regimens"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,"EstAUC","Cmax","Cmin"]
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[null,null,null,null,null,null,"Aminoglycoside Empiric Calculator",null,null,null,null,null,null,null,null,null,null,"Back to Main Menu"]
[]
[]
[]
[null,"Patient Information",null,null,null,null,null,null,null,null,null,null,null,null,null,"Dosing Variables"]
[null,"Age",null,null,85,null,"years"]
[null,"Gender",null,null,"Male",null,null,null,null,null,null,null,null,null,null,"Desired Cmax",null,null,null,{"$f":"IF(G21=\"\",\"\",VLOOKUP(I21,DLsheet!M112:O117,2,FALSE))","v":20}]
[null,"SCr",null,null,1.2,null,"mg/dL",null,null,null,null,null,null,null,null,"Desired Cmin",null,null,null,{"$f":"IF(G21=\"\",\"\",VLOOKUP(I21,DLsheet!M112:O117,3,FALSE))","v":0.25}]
[null,"Height",null,null,165,null,"cm",null,{"$f":"IF(G13=\"inches\",E13,E13/2.54)","v":64.960629921259837},{"$f":"I13*2.54","v":165},null,null,null,null,null,"Vd coefficient",null,null,null,0.3]
[null,"Actual Body Weight",null,"TBW",106,null,"kg",null,{"$f":"IF(G14=\"kg\",E14,E14/2.2)","v":106},null,null,null,null,null,null,"Weight to calculate Vd",null,null,null,"TBW",null,{"$f":"IF(T15>0,T15,IF(T14<1,\"\",VLOOKUP(T14,D14:F21,2,FALSE)))","v":106},{"$f":"IF(ISERROR(I15>DLsheet!H7*EmpiricAMGcalc!E17),\"TBW\",IF(EmpiricAMGcalc!I15>DLsheet!H7*EmpiricAMGcalc!E17,\"AdjBW\",\"TBW\"))","v":"AdjBW"},"Recommended for this patient"]
[null,null,null,"AdjBW",{"$f":"IF(E14<1,\"\",IF(I14>DLsheet!H6*EmpiricAMGcalc!E16,EmpiricAMGcalc!E16+DLsheet!H7*(EmpiricAMGcalc!E14-EmpiricAMGcalc!E16),\"\"))","v":79.245669291338572},null,"kg",null,{"$f":"_xlfn.CONCAT(\"IBW + \",DLsheet!H7,\"* (TBW - IBW) If TBW more than \",DLsheet!G6*100,\"% overweight\")","v":"IBW + 0.4* (TBW - IBW) If TBW more than 30% overweight"},null,null,null,null,null,null,"Manual Dosing Weight (override)",null,null,null,null,null,null,"kg"]
[null,null,null,"IBW",{"$f":"IF(E14<1,\"\",IF(E11=\"Male\",50+2.3*(I13-60),45.5+2.3*(I13-60)))","v":61.409448818897623},null,"kg",null,"M: 2.3*(inches over 60)+50   F: 2.3*(inches over 60)+45.5",null,null,null,null,null,null,"Ke equation",null,null,null,"0.003*CrCl + 0.01"]
[null,null,null,"LBW",{"$f":"IF(E14<1,\"\",IF(E11=\"Male\",L17,M17))","v":63.773259871441702},null,"kg",null,"James Formula",null,null,{"$f":"1.1*I14-128*I14*I14/J13/J13","v":63.773259871441702},{"$f":"1.07*I14-148*I14*I14/J13/J13","v":52.339081726354458},null,null,"Weight to calculate CrCl & Ke",null,null,null,"CrCl AdjBW",null,{"$f":"IF(T18>0,T18,IF(T17<1,\"\",VLOOKUP(T17,D14:F20,2,FALSE)))","v":50.44573855351414},{"$f":"IF(ISERROR(I14>DLsheet!H6*EmpiricAMGcalc!E16),\"TBW\",IF(EmpiricAMGcalc!I14>DLsheet!H6*EmpiricAMGcalc!E16,\"AdjBW\",\"TBW\"))","v":"AdjBW"},"Recommended for this patient"]
[null,null,null,"CrCl TBW",{"$f":"IF(E14<1,\"\",IF(E11=\"Male\",(140-E10)*E14/72/E12,0.85*(140-E10)*E14/72/E12))","v":67.476851851851862},null,"mL/min",null,"(140-Age)*TBW/[72*SCr]  (females * 0.85)",null,null,null,null,null,null,"Manual CrCl (override)",null,null,null,null,null,null,"mL/min"]
[null,null,null,"CrCl AdjBW",{"$f":"IF(E14<1,\"\",IF(E11=\"Male\",(140-E10)*E15/72/E12,0.85*(140-E10)*E15/72/E12))","v":50.44573855351414},null,"mL/min",null,"(140-Age)*AdjBW/[72*SCr]  (females * 0.85)",null,null,null,null,null,null,"Infusion time",null,null,null,0.5,null,null,"hours"]
[null,null,null,"CrCl IBW",{"$f":"IF(E14<1,\"\",IF(E11=\"Male\",(140-E10)*E16/72/E12,0.85*(140-E10)*E16/72/E12))","v":39.091663021288994},null,"mL/min",null,"(140-Age)*IBW/[72*SCr]  (females * 0.85)"]
[null,"Treatment",null,null,"Gent/Tobra",null,"Gram Negative Infections",null,{"$f":"_xlfn.CONCAT(E21,G21)","v":"Gent/TobraGram Negative Infections"}]
[null,null,null,null,null,null,null,null,null,null,"0.003*CrCl + 0.01",{"$f":"V17*0.003+0.01","v":0.16133721566054243}]
[null,null,null,null,null,null,null,null,null,null,"CrCl/Vd",{"$f":"V17/J25*60/1000","v":9.5180638780215363E-2}]
[null,null,null,null,null,null,"AUC-based Dosing Regimen"]
[null,null,null,null,null,null,null,null,"Vd",{"$f":"IF(E14<1,\"\",T13*V14)","v":31.799999999999997},null,null,"L",{"$f":"_xlfn.CONCAT(ROUND(V14,1),\"kg * \",T13,\" L/kg\")","v":"106kg * 0.3 L/kg"}]
[null,null,null,null,null,null,null,null,"Ke",{"$f":"IF(E14<1,\"\",VLOOKUP(T16,K22:L23,2,FALSE))","v":0.16133721566054243},null,null,"h-1",{"$f":"_xlfn.CONCAT(\"CrCl = \",ROUND(V17,1),\"  Ke equation = \",T16)","v":"CrCl = 50.4  Ke equation = 0.003*CrCl + 0.01"}]
[null,null,null,null,null,null,null,null,"t 1/2",{"$f":"IF(E14<1,\"\",ROUND(0.693/J26,1))","v":4.3},null,null,"hours",{"$f":"_xlfn.CONCAT(\"ln(2)/\", ROUND(J26,3))","v":"ln(2)/0.161"}]
[null,null,null,null,null,null,null,null,"Calculated dose",{"$f":"IF(E14<1,\"\",(T11-T12)*J25)","v":628.04999999999995},null,null,"mg","([Desired Cmax] - [Desired Cmin]) * Vd"]
[null,null,null,null,null,null,null,null,"Calculated interval",{"$f":"IF(E14<1,\"\",(LN(T12/T11)/-J26)+T19)","v":27.660668521104117},null,null,"hours","(ln[desired trough]/[desired peak] / [-Ke]) + infusion time"]
[]
[null,null,null,null,null,null,null,null,"Dose",{"$f":"AmgEmpWS!Z1","v":600},null,null,"mg"]
[null,null,null,null,null,null,null,null,"Interval",{"$f":"AmgEmpWS!AA1","v":24},null,null,"hours"]
[null,null,null,null,null,null,null,null,"Infusion Time",0.5,null,null,"hours"]
[null,null,null,null,null,null,null,null,"Calculated Css max",{"$f":"(J31/J25)/(1-EXP(-J26*J32))","v":19.269004125422644},null,null,"mcg/mL"]
[null,null,null,null,null,null,null,null,"Calculated Css min",{"$f":"J34*EXP(-J26*(J32-J33))","v":0.43477493743830797},null,null,"mcg/mL"]

{"sheet":"AmgEmpWS","index":8,"n_rows":100,"n_cols":27,"rows_kept":100,"cut":false,"hidden":true,"merged":[]}
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{"sheet":"DLsheet","index":9,"n_rows":124,"n_cols":22,"rows_kept":124,"cut":false,"hidden":false,"merged":[[52,11,86,15],[52,21,86,27],[4,5,4,7]]}
["Hidden sheet",null,null,null,null,null,null,null,null,"Case-sensitive password for this page:","SIDP",null,null,null,null,null,null,null,null,null,"Yes"]
["Remember to SAVE all work after making edits",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"No"]
[]
[]
[null,"Gender","SCr Limits","Height Toggle","Weight Toggle","AdjBodyWeightRules",null,null,"CrCl DropDown","Weight DropDown"]
[null,"Male",0.4,"cm","kg","If over by",0.3,{"$f":"1+G6","v":1.3},"CrCl TBW","TBW","First Dose"]
[null,"Female",9.9,"inches","pounds","Add ___ of excess",0.4,{"$f":"G7","v":0.4},"CrCl AdjBW","AdjBW","Steady State"]
[null,null,null,null,null,null,null,null,"CrCl IBW","IBW"]
[null,null,null,null,null,null,null,null,"Override","Override"]
[]
[]
[null,"Vancomycin",null,null,"Infusion Duration (how long do you infuse at your center, in hours)",null,null,null,null,null,"Vancomycin"]
[null,"Right side defaults",null,null,500,0.5,null,null,null,null,"Ke equations","Ke eq Explanations"]
[null,null,null,null,750,1,null,null,"Do you use this interval at your site (q#h)?",null,"CrCl*0.0016","Results in most aggressive dosing. Derived from study of younger, mostly male patients at DMC in Det, MI"]
["Desired AUC",500,null,null,1000,1,null,null,8,"Yes","CrCl*0.00083+0.0044","Less aggressive equation. Study included patienst with varying degrees of renal dysfunction. Consider in patients with significant comorbidities (e.g. long-standing DM, CHF, CKD)."]
["Desired Cmax",35,null,null,1250,1.5,null,null,12,"Yes","CrCl/Vd","Basic PK/PD equation, with estimated Ke usually falling between the two equations above. Note, this equation has NOT been validated in clinical studies"]
["Desired Cmin",12.5,null,null,1500,1.5,null,null,18,"No"]
["Weight to calculate CrCl & Ke","CrCl TBW",null,null,1750,2,null,null,24,"Yes"]
["Weight to calculate Vd","TBW",null,null,2000,2,null,null,36,"No"]
["Vd coefficient",0.65,null,null,2250,2.5,null,null,48,"Yes"]
["Ke equation","CrCl*0.00083+0.0044",null,null,2500,2.5]
["Manual CrCl (override)"]
["Manual Dosing Weight (override)"]
["Infusion time",1]
[]
[]
[]
[]
[]
[]
[null,"Type your note text here:",null,null,null,null,null,null,"Empiric output here:",null,null,null,null,null,"Type your note text here:",null,null,null,null,"Two level output here:"]
["Empiric Dosing EMR Note","This is a","year old","patient with [insert PMH, infection source, and culture data here].  ",null,null,null,null,{"$f":"CONCATENATE(B32,\" \",EmpiricVANCOMYCINcalc!E10,\" \",DLsheet!C32,\" \",EmpiricVANCOMYCINcalc!E11,\" \",D32)","v":"This is a  year old  patient with [insert PMH, infection source, and culture data here].  "},null,null,null,null,"Two Level EMR Note","This is a"," follow up dosing note",null,null,null,{"$f":"CONCATENATE(O32,\" \",TwoLevelVANCOMYCINcalc!E10,P32)","v":"This is a Steady State follow up dosing note"}]
[null,"Measured serum creatinine (SCr) is","mg/dL. ",null,null,null,null,null,{"$f":"CONCATENATE(B33,\" \", EmpiricVANCOMYCINcalc!E12,\" \",C33)","v":"Measured serum creatinine (SCr) is  mg/dL. "},null,null,null,null,null,"Current dosing regimen:",null,null,null,null,{"$f":"CONCATENATE(O33,\" \",TwoLevelVANCOMYCINcalc!E11,TwoLevelVANCOMYCINcalc!G11,\" q\",TwoLevelVANCOMYCINcalc!E12,TwoLevelVANCOMYCINcalc!G12)","v":"Current dosing regimen: mg qhrs"}]
[null,"Given a height of","and a weight of ","estimated creatinine clearance is","mL/min (using the","body weight).  ",null,null,{"$f":"CONCATENATE(B34,\" \",EmpiricVANCOMYCINcalc!E13,\" \",EmpiricVANCOMYCINcalc!G13,\" \",DLsheet!C34,EmpiricVANCOMYCINcalc!E14,\" \",EmpiricVANCOMYCINcalc!G14,\", \",DLsheet!D34,\" \",ROUND(EmpiricVANCOMYCINcalc!V17,1),\" \",DLsheet!E34,\" \",EmpiricVANCOMYCINcalc!T17,\" \",DLsheet!F34)","v":{"$error":"#VALUE!"}},null,null,null,null,null,"Levels were collected with the following data after the "," dose:",null,null,null,{"$f":"CONCATENATE(O34,TEXT(TwoLevelVANCOMYCINcalc!E14,\"MM/DD/YYYY\"),\" \",TEXT(TwoLevelVANCOMYCINcalc!F14,\"HH:MM AM/PM\"),P34)","v":"Levels were collected with the following data after the 06/17/2021 06:00 AM dose:"}]
[null,"The following targets were selected for dosing:",null,null,null,null,null,null,{"$f":"B35","v":"The following targets were selected for dosing:"},null,null,null,null,null,"Level 1:  ","mcg/mL",null,null,null,{"$f":"CONCATENATE(\"  - \",O35,CHAR(10),TwoLevelVANCOMYCINcalc!E16,P35,\"  \", TEXT(TwoLevelVANCOMYCINcalc!E17,\"MM/DD/YYYY\"),\" @ \",TEXT(TwoLevelVANCOMYCINcalc!F17,\"HH:MM AM/PM\"))","v":"  - Level 1:  \nmcg/mL  06/17/2021 @ 12:00 PM"}]
[null,"Desired AUC = ","mcg*h/mL",null,null,null,null,null,{"$f":"CONCATENATE(\"  - \",B36,EmpiricVANCOMYCINcalc!T10, \" \",C36)","v":"  - Desired AUC = 500 mcg*h/mL"},null,null,null,null,null,"Level 2: ","mcg/mL",null,null,null,{"$f":"CONCATENATE(\"  - \",O36,CHAR(10),TwoLevelVANCOMYCINcalc!E19,P36,\"  \", TEXT(TwoLevelVANCOMYCINcalc!E20,\"MM/DD/YYYY\"),\" @ \",TEXT(TwoLevelVANCOMYCINcalc!F20,\"HH:MM AM/PM\"))","v":"  - Level 2: \nmcg/mL  06/17/2021 @ 06:00 PM"}]
[null,"Desired Cmax = ","mcg/mL",null,null,null,null,null,{"$f":"CONCATENATE(\"  - \",B37,EmpiricVANCOMYCINcalc!T11,\" \",C37)","v":"  - Desired Cmax = 35 mcg/mL"},null,null,null,null,null,"Desired AUC = ","mcg*h/mL",null,null,null,{"$f":"CONCATENATE(\"  - \",O37,TwoLevelVANCOMYCINcalc!M10,DLsheet!P37)","v":"  - Desired AUC = 500mcg*h/mL"}]
[null,"Desired Cmin = ","mcg/mL",null,null,null,null,null,{"$f":"CONCATENATE(\"  - \",B38,EmpiricVANCOMYCINcalc!T12,\" \",C38)","v":"  - Desired Cmin = 12.5 mcg/mL"},null,null,null,null,null,"Desired Cmax = ","mcg/mL",null,null,null,{"$f":"CONCATENATE(\"  - \",O38,TwoLevelVANCOMYCINcalc!M11,DLsheet!P38)","v":"  - Desired Cmax = 35mcg/mL"}]
[null,"Vd coefficient = ","L/kg",null,null,null,null,null,{"$f":"CONCATENATE(\"  - \",B39,EmpiricVANCOMYCINcalc!T13,\" \",DLsheet!C39)","v":"  - Vd coefficient = 0.65 L/kg"},null,null,null,null,null,"Desired Cmin = ","mcg/mL",null,null,null,{"$f":"CONCATENATE(\"  - \",O39,TwoLevelVANCOMYCINcalc!M12,DLsheet!P39)","v":"  - Desired Cmin = 12.5mcg/mL"}]
[null,"Ke equation = ",null,null,null,null,null,null,{"$f":"CONCATENATE(\"  - \",B40,EmpiricVANCOMYCINcalc!T16)","v":"  - Ke equation = CrCl*0.00083+0.0044"},null,null,null,null,null,"Calculated Ke = ","inverse hours",null,null,null,{"$f":"CONCATENATE(\"  - \",O40,ROUND(TwoLevelVANCOMYCINcalc!E23,3),\" \",P40)","v":{"$error":"#VALUE!"}}]
[null,"Based on above, the following are calculated parameters for AUC-based vancomycin dosing in this patient: ",null,null,null,null,null,null,{"$f":"B41","v":"Based on above, the following are calculated parameters for AUC-based vancomycin dosing in this patient: "},null,null,null,null,null,"Calculated half life = ","hours",null,null,null,{"$f":"CONCATENATE(\"  - \",O41,ROUND(TwoLevelVANCOMYCINcalc!E24,1),\" \",P41)","v":{"$error":"#VALUE!"}}]
[null,"Calculated Vd = ","L",null,null,null,null,null,{"$f":"CONCATENATE(\"  - \",B42,EmpiricVANCOMYCINcalc!E26,C42)","v":"  - Calculated Vd = L"},null,null,null,null,null,"Calculated Vd = ","Liters",null,null,null,{"$f":"CONCATENATE(\"  - \",O42,ROUND(TwoLevelVANCOMYCINcalc!E27,1),\" \",P42)","v":{"$error":"#DIV/0!"}}]
[null,"Calculated Ke = ","inverse hours",null,null,null,null,null,{"$f":"CONCATENATE(\"  - \",B43,ROUND(EmpiricVANCOMYCINcalc!E27,3),\" \",C43)","v":{"$error":"#VALUE!"}},null,null,null,null,null,"Updated dose will be vancomycin IV ",null,null,null,null,{"$f":"CONCATENATE(O43,TwoLevelVANCOMYCINcalc!M23,TwoLevelVANCOMYCINcalc!P23,\" q\",TwoLevelVANCOMYCINcalc!M24,TwoLevelVANCOMYCINcalc!P24)","v":{"$error":"#DIV/0!"}}]
[null,"Calculated half-life = ","hours",null,null,null,null,null,{"$f":"CONCATENATE(\"  - \",B44,ROUND(EmpiricVANCOMYCINcalc!E28,1),\" \",DLsheet!C44)","v":{"$error":"#VALUE!"}},null,null,null,null,null,"Which is predicted to achieve the following parameters:",null,null,null,null,{"$f":"O44","v":"Which is predicted to achieve the following parameters:"}]
[null,"Empiric dose will be vancomycin IV ",null,null,null,null,null,null,{"$f":"CONCATENATE(B45,EmpiricVANCOMYCINcalc!Q26,EmpiricVANCOMYCINcalc!T26,\" q\",EmpiricVANCOMYCINcalc!Q27,EmpiricVANCOMYCINcalc!T27)","v":{"$error":"#VALUE!"}},null,null,null,null,null,"Estimated AUC = ","mcg*h/mL",null,null,null,{"$f":"CONCATENATE(\"  - \",O45,ROUND(TwoLevelVANCOMYCINcalc!M26,1),\" \",P45)","v":{"$error":"#DIV/0!"}}]
[null,"Which is predicted to achieve the following parameters:",null,null,null,null,null,null,{"$f":"B46","v":"Which is predicted to achieve the following parameters:"},null,null,null,null,null,"Estimated Cmax = ","mcg/mL",null,null,null,{"$f":"CONCATENATE(\"  - \",O46,ROUND(TwoLevelVANCOMYCINcalc!M27,1),\" \",P46)","v":{"$error":"#DIV/0!"}}]
[null,"Estimated AUC = ","mcg*h/mL",null,null,null,null,null,{"$f":"CONCATENATE(\"  - \",B47,ROUND(EmpiricVANCOMYCINcalc!Q29,1), \" \",C47)","v":{"$error":"#VALUE!"}},null,null,null,null,null,"Estimated Cmin = ","mcg/mL",null,null,null,{"$f":"CONCATENATE(\"  - \",O47,ROUND(TwoLevelVANCOMYCINcalc!M28,1),\" \",P47)","v":{"$error":"#DIV/0!"}}]
[null,"Estimated Cmax = ","mcg/mL",null,null,null,null,null,{"$f":"CONCATENATE(\"  - \",B48,ROUND(EmpiricVANCOMYCINcalc!Q30,1),\" \",C48)","v":{"$error":"#VALUE!"}}]
[null,"Estimated Cmin = ","mcg/mL",null,null,null,null,null,{"$f":"CONCATENATE(\"  - \",B49,ROUND(EmpiricVANCOMYCINcalc!Q31,1),\" \",C49)","v":{"$error":"#VALUE!"}}]
[]
[]
[null,null,null,null,null,null,null,null,null,null,"Empiric Note",null,null,null,null,null,null,null,null,"Two-level Note"]
["Subjective and Objective Data:",{"$f":"CONCATENATE(I32,I33,I34)","v":{"$error":"#VALUE!"}},null,null,null,null,null,null,null,null,null,{"$f":"CONCATENATE(A53,CHAR(10),I32,I33,CHAR(10),CHAR(10),I34,CHAR(10),CHAR(10),I35,CHAR(10),CHAR(10),I36,CHAR(10),I37,CHAR(10),I38,CHAR(10),I39,CHAR(10),I40,CHAR(10),CHAR(10),A66,CHAR(10),I41,CHAR(10),I42,CHAR(10),I43,CHAR(10),I44,CHAR(10),CHAR(10),A72,CHAR(10),I45,CHAR(10),CHAR(10),I46,CHAR(10),I47,CHAR(10),I48,CHAR(10),I49)","v":{"$error":"#VALUE!"}},null,null,null,null,null,null,null,null,null,{"$f":"CONCATENATE(A53,CHAR(10),T32,CHAR(10),T33,CHAR(10),CHAR(10),T34,CHAR(10),CHAR(10),T35,CHAR(10),CHAR(10),T36,CHAR(10),CHAR(10),T37,CHAR(10),T38,CHAR(10),T39,CHAR(10),CHAR(10),CHAR(10),A66,CHAR(10),T40,CHAR(10),T41,CHAR(10),T42,CHAR(10),CHAR(10),A72,CHAR(10),T43,CHAR(10),CHAR(10),T44,CHAR(10),T45,CHAR(10),T46,CHAR(10),T47)","v":{"$error":"#VALUE!"}}]
[]
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[]
["Dosing Targets:","The following targets were selected for dosing:\n  -Desired AUC = 500 mcg*h/mL\n  -Desired Cmax = 35 mcg/mL\n  -Desired Cmin = 12.5 mcg/mL\n  -Vd coefficient = 0.65 L/kg\n  -Ke equation = CrCl*0.00083+0.0044"]
[]
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["Calculations:",{"$f":"CONCATENATE(I41,CHAR(10),\"  -\",I42,CHAR(10),\"  -\",I43,CHAR(10),\"  -\",I44)","v":{"$error":"#VALUE!"}}]
[]
[]
[]
[]
[]
["Prescribed Dosing:",{"$f":"I45","v":{"$error":"#VALUE!"}}]
[]
["Predicted Outcomes:",{"$f":"CONCATENATE(I46,CHAR(10),\"  -\",I47,CHAR(10),\"  -\",I48,CHAR(10),\"  -\",I49)","v":{"$error":"#VALUE!"}}]
[]
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[null,"Aminoglycoside",null,null,"Infusion Duration (how long do you infuse at your center, in hours)",null,null,null,null,null,"Aminoglycosides"]
[null,"Right side defaults",null,null,250,0.5,null,null,null,null,"Ke equations","Ke eq Explanations"]
[null,null,null,null,300,0.5,null,null,null,null,"0.003*CrCl + 0.01"]
[null,null,null,null,350,0.5,null,null,null,null,"CrCl/Vd","Basic PK/PD equation, with estimated Ke usually falling between the two equations above. Note, this equation has NOT been validated in clinical studies"]
[null,null,null,null,400,0.5]
[null,null,null,null,450,0.5]
["Weight to calculate CrCl & Ke",null,null,null,500,0.5]
["Weight to calculate Vd",null,null,null,550,0.5,null,null,null,"Treatment","Treatment",null,null,"Desired Cmax","Desired Cmin"]
["Vd coefficient",0.3,null,null,600,0.5,null,null,null,"Gent/Tobra","Cystitis",null,"Gent/TobraCystitis",4,1]
["Ke equation","0.003*CrCl + 0.01",null,null,650,0.5,null,null,null,"Amikacin","Gram Negative Infections",null,"Gent/TobraGram Negative Infections",20,0.25]
["Manual CrCl (override)",null,null,null,700,0.5,null,null,null,null,"Synergy",null,"Gent/TobraSynergy",4,1]
["Manual Dosing Weight (override)",null,null,null,750,0.5,null,null,null,null,null,null,"AmikacinCystitis",17.5,4]
["Infusion time",0.5,null,null,800,0.5,null,null,null,null,null,null,"AmikacinGram Negative Infections",70,1]
[null,null,null,null,850,0.5,null,null,null,null,null,null,"AmikacinSynergy","Use gentamicin","Use gentamicin"]
[null,null,null,null,900,0.5]
["Interval","Calculated interval between",null,null,950,0.5]
[12,0,7,"hours",1000,0.5]
[18,7.01,16,"hours"]
[24,16.010000000000002,33,"hours"]
[36,33.01,44,"hours"]
[48,44.01,100,"hours"]

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[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Back to Main Menu"]
[]
[]
[null,null,null,null,null,null,null,null,null,null,null,"Acknowledgements"]
[]
[]
[null,null,null,null,null,"Chief Designer",null,null,null,null,null,"Raymond Yost, PharmD"]
[]
[null,null,null,null,null,null,null,null,null,null,null,"Manager, Pharmacy Services"]
[null,null,null,null,null,null,null,null,null,null,null,"DMC Detroit Receiving Hospital"]
[null,null,null,null,null,null,null,null,null,null,null,"Detroit, MI  USA"]
[]
[]
[]
[null,null,null,null,null,"Associate Editors",null,null,null,null,null,"Jason Pogue, PharmD, BCPS, BCIDP"]
[]
[null,null,null,null,null,null,null,null,null,null,null,"Clinical Pharmacist Specialist, Infectious Diseases"]
[null,null,null,null,null,null,null,null,null,null,null,"University of Michigan, College of Pharmacy"]
[null,null,null,null,null,null,null,null,null,null,null,"Ann Arbor, MI  USA"]
[null,null,null,null,null,null,null,null,null,null,null,"Past President, SIDP"]
[]
[]
[null,null,null,null,null,null,null,null,null,null,null,"Ryan Mynatt, PharmD, BCIDP"]
[]
[null,null,null,null,null,null,null,null,null,null,null,"Clinical Pharmacist Specialist, Infectious Diseases"]
[null,null,null,null,null,null,null,null,null,null,null,"University of Kentucky Medical Center"]
[null,null,null,null,null,null,null,null,null,null,null,"Lexington, KY  USA"]
[]
[]
[]
[null,null,null,null,null,"Key Contributors"]
[null,null,null,null,null,null,null,null,null,null,null,"Michael Rybak, DMC Detroit Receiving Hospital and Wayne State University"]
[null,null,null,null,null,null,null,null,null,null,null,"Kyle Murray, DMC Harper University Hospital"]
[null,null,null,null,null,null,null,null,null,null,null,"Jing Zhao, DMC Harper University Hospital"]
[null,null,null,null,null,null,null,null,null,null,null,"Christine Yost, Beaumont Health"]